The Thom lab works to understand genetic factors that regulate blood cell formation and function
We are very interested in creating tailored blood cells for neonates and infants,
whether by modifying donated adult blood cells and platelets - or alternatively creating new blood products from iPSCs.
Interested in discussing a position or collaboration?
We need to enhance blood cell production.
Shortages in donor-derived blood products have driven us to improve in vitro blood cell production from iPSCs or other alternative sources.
iPSC models recapitulate many aspects of blood cell differentiation and can produce clinically relevant cell types. iPSCs can also model complex disease phenotypes.
Open Positions
We are always interested to speak with interested graduate students and post-docs!
Potential projects involve next-generation sequencing analyses of cultured induced pluripotent stem cells (iPSCs) and mouse models to understand blood formation and function.
An interest in bioinformatics and statistical genetics is a plus!
We have open positions for graduate students, fellows, and post-docs
Current and future projects
Training machine learning algorithms to recognize blood trait-specific epigenetic signals and regulatory genomic loci.
Expanding Mendelian randomization and genetic colocalization pipelines to understand blood trait-disease links
Developing single cell analyses to define hematopoietic pathways in iPSCs and human tissues.
Developing in vivo and in vitro models to explore how tropomyosins and actin regulate blood cell formation, differentiation, and function